Exonuclease 1 (EXO1) gene variation and melanoma risk
نویسندگان
چکیده
منابع مشابه
Human exonuclease 1 (EXO1) activity characterization and its function on flap structures
Human exonuclease 1 (EXO1) is involved in multiple DNA metabolism processes, including DNA repair and replication. Most of the fundamental roles of EXO1 have been described in yeast. Here, we report a biochemical characterization of human full-length EXO1. Prior to assay EXO1 on different DNA flap structures, we determined factors essential for the thermodynamic stability of EXO1. We show that ...
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A two-hybrid screen was used to identify Saccharomyces cerevisiae genes encoding proteins that interact with MSH2. One gene was found to encode a homologue of Schizosaccharomyces pombe EXO1, a double-stranded DNA-specific 5*–3* exonuclease. S. cerevisiae EXO1 interacted with both S. cerevisiae and human MSH2 in two-hybrid and coimmunoprecipitation experiments. exo1 mutants showed a mutator phen...
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متن کاملThe WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.
The WRN helicase/exonuclease protein is required for proper replication fork recovery and maintenance of genome stability. However, whether the different catalytic activities of WRN cooperate to recover replication forks in vivo is unknown. Here, we show that, in response to replication perturbation induced by low doses of the TOP1 inhibitor camptothecin, loss of the WRN exonuclease resulted in...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2012
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2011.12.005